Fig. 6. Advantage of sequestration over reduction in phospotransfer rate.

A The peak of the response (O_max) as a function of the maximum input, I₀, for different extents of sequestration, determined by the ratios of the non-cognate RRs, RR_nc, to the cognate RR, RR_c, indicated. B O_max as a function of I₀ for different phosphotransfer rates indicated. C O_max as a function of I₀ for different ratios of the non-cognate RR_nc/RR_c indicated, in the absence of positive autoregulation. Here, we also set protein degradation rates to zero, to eliminate the threshold introduced by the lack of proteins. Model predictions were obtained by solving Eqs. (20–47) (“Methods” section) using parameter values listed in Table S4.