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. 2023 Jul 25;13:12029. doi: 10.1038/s41598-023-39260-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LEfSe analysis of human protein classes using an alpha value of 0.05 for the factorial Kruskal–Wallis test among classes and a threshold of 2.0 on the logarithmic LDA score for discriminative features. (A-C) Using outgrowth of CMA at visit 12 months as class, Yes: outgrowth of CMA at 12 months; no: no outgrowth of at 12 months. Plot of discriminative features at (A) baseline visit; (B) visit 6 months; (C) visit 12 months. (D–F) Pairwise comparison between visits within the group with outgrowth of CMA, using visit as class. (D) visit 6 months (T6M) versus baseline (T0M); (E) visit 12 months (T12M) versus baseline (T0M); (F) visit 12 months (T12M) versus visit 6 months (T6M). (G–I) Pairwise comparison between visits within the group with persistent CMA, using visit as class. (G) visit 6 months (T6M) versus baseline (T0M); (H) visit 12 months (T12M) versus baseline (T0M); (I) visit 12 months (T12M) versus visit 6 months (T6M).