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. 2023 Jul 25;13:12057. doi: 10.1038/s41598-023-37685-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pepsin digestion significantly alters aECM protein composition. (A) Schematic demonstrating critical points during the hydrogel formation process in which samples were taken for mass spectrometry. (B) Total unique proteins identified by mass spectrometry, mean ± SEM (n = 3), ***p < 0.001, ****p < 0.0001. (C) Percentage of total matrisome composition compared to total proteins. (D) Heatmap of Top 25 ECM Proteins in aECM powder samples (percent spectral hits compared to total sample spectral hits) compared to soluble aECM and aECM hydrogels. (E) Proportion of ECM protein types compared to total ECM composition, mean ± SEM (n = 3), **p < 0.01, ***p < 0.001, ****p < 0.0001. (E) Proportion of individual ECM proteins compared to total ECM composition categorized as (F) fibrillar collagens (G) other collagens, and (H) ECM glycoproteins, mean ± SEM (n = 3), **p < 0.01, ***p < 0.001, ****p < 0.0001.