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. 2023 Jun 30;9(7):e17849. doi: 10.1016/j.heliyon.2023.e17849

Fig. 3.

Fig. 3

Depletion of circHMGA2 attenuated pyroptosis in H/R-induced HCMs. (A) Effect of circHMGA2 knockdown on the expression of pyroptosis-related proteins (NLRP3, cleaved caspase-1, IL-1β and GSDMD-N) was detected by western blotting. (B) Effect of circHMGA2 knockdown on the expression of inflammatory factors (TNF-α, IL-1β, IL-10 and IL-10) H/R-induced HCMs was detected by western blotting. (C–F) Effect of circHMGA2 knockdown on the expression of inflammatory factors, including IL-1β (C), TNF-α (D), IL-18 (E) and IL-10 (F) was detected by ELISA assays in H/R-induced HCMs. **p < 0.01 vs. H/R; #p < 0.05 and ##p < 0.01 vs. H/R + sh-NC.