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. 2023 Jun 30;9(7):e17849. doi: 10.1016/j.heliyon.2023.e17849

Fig. 5.

Fig. 5

CircHMGA2 knockdown inhibited myocardial injury in MI/R mice. (A) The expression of circHMGA2 was detected by RT-qPCR in the myocardial tissues of MI/R mice injected with HCMs stably expressing sh-circHMGA2. (B) The levels of EF and FS was detected by echocardiography in MI/R mice injected with HCMs stably expressing sh-circHMGA2. (C–D) The levels of LVAWd (C) and LVPWd (D) were detected by echocardiography in MI/R mice injected with HCMs stably expressing sh-circHMGA2. (E–F) The serum myocardial injury markers, including CK-MB (E) and LDH (F) was detected by ELISA assays in MI/R mice injected with HCMs stably expressing sh-circHMGA2. (G) The degree of myocardial injury in the myocardial tissues was detected by HE staining in MI/R mice injected with HCMs stably expressing sh-circHMGA2. (H) Apoptosis of myocardial tissues was detected by TUNEL staining in MI/R mice injected with HCMs stably expressing sh-circHMGA2. **p < 0.01 and ***p < 0.001 vs. sham; #p < 0.05 and ##p < 0.01 vs. MI/R + sh-NC.