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. 2023 Jul 11;5:100161. doi: 10.1016/j.crphar.2023.100161

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© 2023 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Effects of Apigenin on CUMS-induced depression in mice. (A) Effect of API on duration of grooming in mice on day 1 of the sucrose splash test. (B) Effect of API on duration of grooming on day 14 of the sucrose splash test. (C) API increases frequency of open arm entry in the elevated plus maze test. (D) API increases duration of open arm entry in the elevated plus maze test. (E) API shortened duration of immobility in the forced swimming test. (F) API shortened duration of immobility in the tail suspension test. (n = 10, *P < 0.05 and **P < 0.01 v control; *P < 0.05, ***P < 0.01 and ***P < 0.001 v stress). Data expressed as mean ± SD. One-way analysis of variance (ANOVA) followed by Tukey's multiple comparison test.