. Author manuscript; available in PMC: 2023 Sep 28.

Published in final edited form as: Alzheimers Dement. 2023 Jan 26;19(7):3078–3086. doi: 10.1002/alz.12952

TABLE 7.

Sample size needed for cognitive measures in the hypothetical clinical trial

		Number needed in each group

Test	CN + MCI	1 year	2 years
CDR-SOB	Full sample	32004	2663
	High risk	8107	1366
MMSE	Full sample	5222	2785
	High risk	2340	935
ADAS-Cog	Full sample	216203	11131
	High risk	16268	1718

Note: Full sample: Participants without PHS cutoff stratification.

Abbreviations: ADAS-Cog, Alzheimer’s Disease Assessment Scale–Cognitive Subscale; CDR-SOB, Clinical Dementia Rating Scale Sum of Boxes; CN, cognitively normal; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; PHS, polygenic hazard score.