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. 2023 Jul 13;9(7):e18196. doi: 10.1016/j.heliyon.2023.e18196

Fig. 2.

Fig. 2

Oral administration of pasteurized A. muciniphila improves glucose homeostasis during a HFD45%. Effects of an oral administration of vehicle or pasteurized A. muciniphila on (A) fasted glycemia at the beginning (D0) and the end of the protocol (WK11), **p < 0.01 vs HFD Vehicle, (B) fasted insulinemia at the beginning (D0) and the end of the protocol (WK11), *p < 0.05 vs HFD Vehicle, (C) HOMA IR index calculated as insulinemia (mU/L) x glycemia (mmol/L)/22,5 at the beginning (D0) and the end of the protocol (WK11), **p < 0.01 vs HFD Vehicle, (D) Oral glucose tolerance test (OGTT) glycemia evolution before and after an oral load of glucose (2 g/kg of body weight), *p < 0.05, **p < 0.01 vs HFD Vehicle, (E) the average area under the curve (AUC) of the glycemia measured during the OGTT, **p < 0.01 vs HFD Vehicle, (F) Insulinemia before and 15 min after an oral load of glucose, ***p < 0.001 vs HFD Vehicle. The associated p values were obtained using a 2-way ANOVA followed by Bonferroni's post-hoc test, except for panel E using an unpaired t-test. n = 8–10 per group.