Table 1.
MR results of causal links between gut microbiome and kidney stones risk.
| Group | Gut microbiota | MR method | No.SNP | OR (95% CI) | p-value | F-statistic | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genus | Oxalobacter | Inverse variance weighted | 11 | 0.99 (0.90–1.09) | 0.811 | 21.35 | MR Egger | 11 | 0.78 (0.50–1.24) | 0.319 | Weighted median | 11 | 0.97 (0.85–1.11) | 0.667 | Simple mode | 11 | 0.96 (0.76–1.21) | 0.729 | Weighted mode | 11 | 0.96 (0.77–1.20) | 0.730 | ||||
| Order | Actinomycetales | Inverse variance weighted | 4 | 0.79 (0.65–0.96) | 0.020 | 21.51 | MR Egger | 4 | 0.75 (0.48–1.16) | 0.322 | Weighted median | 4 | 0.79 (0.61–1.02) | 0.066 | Simple mode | 4 | 0.74 (0.52–1.04) | 0.178 | Weighted mode | 4 | 0.79 (0.60–1.03) | 0.183 | ||||
| Family | Actinomycetaceae | Inverse variance weighted | 4 | 0.79 (0.65–0.96) | 0.019 | 21.57 | MR Egger | 4 | 0.75 (0.48–1.15) | 0.320 | Weighted median | 4 | 0.79 (0.61–1.01) | 0.058 | Simple mode | 4 | 0.74 (0.52–1.05) | 0.188 | Weighted mode | 4 | 0.79 (0.60–1.03) | 0.180 | ||||
| Family | Clostridiaceae1 | Inverse variance weighted | 10 | 0.80 (0.67–0.96) | 0.015 | 20.28 | MR Egger | 10 | 0.73 (0.43–1.24) | 0.276 | Weighted median | 10 | 0.84 (0.66–1.08) | 0.184 | Simple mode | 10 | 0.86 (0.61–1.22) | 0.430 | Weighted mode | 10 | 0.86 (0.63–1.18) | 0.386 | ||||
| Genus | Clostridiumsensustricto 1 | Inverse variance weighted | 7 | 0.81 (0.67–0.98) | 0.030 | 20.60 | MR Egger | 7 | 1.13 (0.70–1.83) | 0.637 | Weighted median | 7 | 0.86 (0.66–1.12) | 0.256 | Simple mode | 7 | 0.85 (0.58–1.26) | 0.455 | Weighted mode | 7 | 0.86 (0.62–1.20) | 0.417 | ||||
| Genus | Haemophilus | Inverse variance weighted | 9 | 1.16 (1.01–1.33) | 0.032 | 23.42 | MR Egger | 9 | 1.06 (0.78–1.44) | 0.705 | Weighted median | 9 | 1.14 (0.95–1.36) | 0.172 | Simple mode | 9 | 1.07 (0.83–1.37) | 0.626 | Weighted mode | 9 | 1.13 (0.89–1.42) | 0.338 | ||||
| Genus | Hungatella | Inverse variance weighted | 5 | 0.86 (0.74–0.99) | 0.040 | 20.43 | MR Egger | 5 | 1.17 (0.49–2.83) | 0.744 | Weighted median | 5 | 0.85 (0.71–1.03) | 0.098 | Simple mode | 5 | 0.85 (0.68–1.07) | 0.243 | Weighted mode | 5 | 0.86 (0.68–1.07) | 0.242 | ||||
| Genus | Ruminococcaceae (UCG010) | Inverse variance weighted | 6 | 1.38 (1.04–1.84) | 0.028 | 21.43 | MR Egger | 6 | 1.15 (0.49–2.72) | 0.759 | Weighted median | 6 | 1.27 (0.94–1.72) | 0.115 | Simple mode | 6 | 1.31 (0.85–2.02) | 0.280 | Weighted mode | 6 | 1.28 (0.92–1.79) | 0.203 | ||||
| Genus | Subdoligranulum | Inverse variance weighted | 11 | 1.27 (1.06–1.52) | 0.009 | 21.12 | MR Egger | 11 | 0.98 (0.62–1.55) | 0.936 | Weighted median | 11 | 1.18 (0.93–1.51) | 0.179 | Simple mode | 11 | 1.18 (0.85–1.63) | 0.348 | Weighted mode | 11 | 1.18 (0.87–1.60) | 0.317 |