Table 1.
Genes regulating Ca2+ homeostasis statistically significantly over- or under-expressed in cell lines with regular response to stimulation
| Gene symbol | Description (upon NCBI/UniProt gene summary) | Expression status |
|---|---|---|
| CACNA2D3 | Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2/delta. A member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex (consists of alpha-1, alpha-2/delta, beta, and gamma subunits). Mediates the influx of calcium ions into the cell upon membrane polarization.26. | Downregulated |
| CHERP | Calcium Homeostasis Endoplasmic Reticulum Protein, enables transmembrane transporter binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and of sequestered calcium ion into cytosol. Acts upstream of or within cellular calcium ion homeostasis.27. | Upregulated |
| LETM1 | Leucine Zipper And EF-Hand Containing Transmembrane Protein 1. Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Maintains the mitochondrial tubular shapes and is required for normal mitochondrial morphology.28,29. | Upregulated |
| MCOLN1 | Mucolipin TRP Cation Channel 1. Member of the transient receptor potential (TRP) cation channel gene family. Permeable to Ca2+, Fe2+, Na+, K+, and H+, and is modulated by changes in Ca2+ concentration. The membrane channel is localized in lysosomes.30,31,32. | Upregulated |
| SEC61A1 | SEC61 Translocon Subunit Alpha 1. Mediates transport of signal peptide-containing precursor polypeptides. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis.33. | Upregulated |
| SLC25A23 | Solute Carrier Family 25 Member 23. Predicted to enable ATP transmembrane transporter activity. Involved in calcium import into the mitochondrion; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response.34. | Upregulated |
| STRIT1 | Small Transmembrane Regulator Of Ion Transport 1. Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitory peptides sarcolipin, phospholamban and myoregulin (predicted from homology to DWORF). | Upregulated |
| TMEM109 | Transmembrane Protein 109. Predicted to form voltage-gated calcium and potassium channels.35. | Upregulated |
| TPCN2 | Two Pore Segment Channel 2. Intracellular endolysosomal channel initially characterized as a non-selective Ca2+-permeable channel activated by NAADP, it is also a highly-selective Na+ channel activated directly by PI(3,5)P2.36,37. | Upregulated |
| TRPC7 | Transient Receptor Potential Cation Channel Subfamily C Member 7. Predicted to enable inositol-1,4,5-trisphosphate binding activity and store-operated calcium channel activity; involved in metal ion transport; regulation of cytosolic calcium ion concentration.38. | Upregulated |