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. 2023 Jul 12;14:1219194. doi: 10.3389/fendo.2023.1219194

Figure 3.

Figure 3

Effect of maternal exercise on vasodilatation function in mesenteric arteries from 3M male offspring. (A) Original traces of concentration-dependent vasodilatation evoked by acetylcholine (ACh, 10-9–10-5 M). Mesenteric artery rings were contracted with NE (10-5 M). (B) Corresponding concentration–response curves for endothelial-dependent vasodilatation to ACh. (C) Maximum relaxation (%) in response to 10-5 M ACh. (D) Original traces of concentration-independent vasodilatation evoked by sodium nitroprusside (SNP, 10-9–10-5 M). (E) Corresponding concentration–response curves for endothelial-independent vasodilatation to SNP. (F) Maximum relaxation (%) in response to 10-5 M SNP. (G) Endothelium-dependent vasodilatations to ACh were determined in the absence and presence of L-NAME (10-4 M, NOS inhibitor). (H) Contribution of NO-derived vasodilators in mesenteric arteries of 3M male offspring (n=3-6 animals per group). * P<0.05 compared with p-WKY-SED; # P<0.05 compared with p-SHR-SED.