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. 2023 Jul 12;17:1202027. doi: 10.3389/fnins.2023.1202027

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Copyright © 2023 Nakamura, Nonaka, Oyama, Jo, Kamo, Nuermaimaiti, Akamatsu, Ishikawa and Hattori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Grafted human iPSC-derived mDA neurons improve the motor functions of PD-model mice. The number of apomorphine-induced rotations (left) and the ratio to that of before the operation (right). (A) mDA progenitor transplantation: n = 18, sham: n = 18, mean ± SEM. The p-values were comparisons with the sham group at the same time-point using Student’s t-test. (B) Graph of results with separate the graft cells from primary neurospheres (n = 11) and secondary neurospheres (n = 7). The p-values were comparisons with the sham group at the same time-point using Steel’s multiple comparison test. *p < 0.05, **p < 0.01. iPSCs induced pluripotent stem cells; PD, Parkinson’s disease; mDA, midbrain dopaminergic.