Figure 5.

WGCNA. (A) Determine the best soft threshold. The soft threshold value of 18 was determined as the optimal choice for constructing a scale-free network based on the position of the red line (R^{2 =} 0.9). (B) The variance is in the top 50% of the gene cluster dendrogram, with each branch of the graph representing a gene and each color below representing a co-expression module. (C) Heat map of module-trait relationships, where each color represents a co-expression module and the values represent module-trait correlation coefficients and p-values. It can be seen that the red module has the highest correlation with OA. (D) Scatterplot of correlations between gene significance (GS) and module membership (MM) in red modules. (E) Venn diagram of the intersection of ARDEGs and Key genes in the red module.