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. 2023 Jul 12;13:1211984. doi: 10.3389/fonc.2023.1211984

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Copyright © 2023 Bernardo, Behrends, Klein, Kuntze, Timmermann and von Neubeck

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CV assay comparing the relative number of proliferating cells (proliferation; normalized to matched control) of 0 Gy control vs. treatment of HT-1080, GCT, and RD cells following (A) radiation only with 4 and 8 Gy X (light/dark blue) or 4 and 8 Gy H radiation (light/dark red). (B) Dox treatment with 10 nM DoxA (before), DoxB (before and after), or DoxC (after). Dox treatment schedule details in Figure 1D (C–F) Combined treatment with DoxA, DoxB, or DoxC and (C) 4 Gy X (blue), (D) 8 Gy X (blue), (E) 4 Gy H (red), and (F) 8 Gy H (red). n ≥ 3, statistical analysis: paired t-test for whole curve or unpaired t-test for the 96 h timepoint (shown as whole curve | 96 h) comparing treatment vs. 0 Gy control. p values > 0.05 (not significant, ns), < 0.05 (*), < 0.01 (**), and < 0.001 (***) were considered statistically significant.