Table 1.
The clinical characteristics between treatment-resistant and treatment-responsive group.
| Treatment-resistant (n=55) | Treatment-responsive (n=96) | p | |
|---|---|---|---|
| Age (years) | 61 ± 12 | 61 ± 11 | 0.771 |
| White blood cells (109/L) | 9.02 ± 4.30 | 10.26 ± 4.16 | 0.083 |
| Hemoglobin (g/L) | 77.36 ± 18.30 | 86.60 ± 19.81 | 0.005 |
| Platelet (109/L) | 238.42 ± 101.08 | 298.19 ± 109.50 | 0.001 |
| Serum albumin (g/L) | 32.10(28.30–37.30) | 31.45(26.75–36.33) | 0.574 |
| Serum globulin (g/L) | 30.67 ± 7.77 | 33.07 ± 8.13 | 0.078 |
| Serum creatinine (μmol/L) | 643.28 ± 295.19 | 258.71 ± 242.61 | <0.001 |
| ESR (mm/h) | 66.73 ± 36.59 | 71.36 ± 40.30 | 0.484 |
| CRP (mg/L) | 18.40(7.25–68.20) | 38.14(5.77–95.85) | 0.188 |
| C3 (mg/L) | 693.40 ± 261.76 | 802.48 ± 342.59 | 0.030 |
| C4 (mg/L) | 214.33 ± 105.50 | 218.97 ± 105.86 | 0.796 |
| IgA (mg/L) | 2413.93 ± 1435.34 | 2635.28 ± 1572.43 | 0.392 |
| IgG (g/L) | 14.04 ± 5.96 | 15.61 ± 5.54 | 0.104 |
| IgM (mg/L) | 860.00 ± 456.19 | 1054.42 ± 630.60 | 0.047 |
| ALT (U/L) | 9.90(5.40–14.30) | 14.90(8.90–24.13) | 0.001 |
| AST (U/L) | 16.00(12.60–25.90) | 18.60(14.90–31.88) | 0.046 |
| TBIL (μmol/L) | 5.30(4.20–7.00) | 6.60(4.70–8.70) | 0.024 |
| DBIL (μmol/L) | 2.50(1.90–3.80) | 2.90(1.90–4.08) | 0.393 |
| BUN (mmol/L) | 21.04 ± 10.54 | 11.62 ± 8.53 | 0.001 |
| Neutrophil (109/L) | 7.10 ± 3.92 | 8.10 ± 4.85 | 0.197 |
| Lymphocyte (109/L) | 1.00(0.60–1.40) | 1.10(0.70–1.60) | 0.519 |
| Eosinophil (109/L) | 0.12(0.03–0.20) | 0.10(0.00–0.30) | 0.451 |
| Total Prednisolone, g Median(Q1,Q3) | 4.69(3.60,5.00) | 4.96(4.95,6.30) | <0.001 |
| Total CTX, g Median(Q1,Q3) | 2.40(1.80,3.60) | 4.80(3.60,4.80) | <0.001 |
| MP, n (%) | 14 (25.5%) | 12 (12.5%) | 0.043 |
| PE, n (%) | 25 (45.5%) | 22 (22.9%) | 0.004 |
ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, direct bilirubin; BUN, blood urea nitrogen; CTX, cyclophosphamide; MP, methylprednisone pulse; PE, plasma exchange.