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. 2023 Jul 12;14:1194931. doi: 10.3389/fimmu.2023.1194931

Figure 6.

Figure 6

Gut colonization with ETBF reshapes the metastatic niche in the liver. (A) Representative images of IHC analysis of Ki67, CD3, N-cadherin, E-cadherin, fibronectin, CD31, and VEGFR2 in the livers from intraductal 4T1 tumor-bearing mice, sham control group or ETBF-infected group. (B) Flow cytometry analyses of levels of CD4+ T cells, CD8+ T cells, CD11b+ myeloid cells, CD11b+F4/80+ macrophages, CD11c+ dendritic cells, and CD4+Foxp3+ T regulatory cells in the livers of intraductal 4T1 tumor-bearing mice from sham control group or the group bearing enteric ETBF colonization post 1 week and 4 weeks of tumor implant. Y-axis represents the number of cells per liver. Data are representative of three independent experiments analyzed separately; p < 0.05*, p < 0.005**, p < 0.0001***, ns (nonsignificant).