Figure 7.

ETBF enteric infection modulates the metastatic niche in the lungs. (A) Representative images of IHC analysis of Ki67, CD3, N-cadherin, E-cadherin, fibronectin, CD31, and VEGFR2 in the lungs from intraductal 4T1 tumor-bearing mice, sham control or ETBF-infected. (B) Flow cytometry analyses of levels of CD4⁺ T cells, CD8⁺ T cells, CD11b⁺ myeloid cells, CD11b⁺F4/80⁺ macrophages, CD11c⁺ dendritic cells, and CD4⁺Foxp3⁺ T regulatory cells in the lungs of tumor-bearing mice sham-control or infected with ETBF for 1 week and 4 weeks. Y-axis represents the number of cells per liver. Data are representative of three independent experiments analyzed separately; p < 0.05*, p < 0.005**, p < 0.0001***, ns (nonsignificant).