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. 2023 Jul 12;14:1115660. doi: 10.3389/fgene.2023.1115660

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Copyright © 2023 Guo, Zhao, Cao, Li, Yang, Tian, Dai, Song, Ren and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune analysis of CEL in PDAC. (A) Comparing CEL-high and CEL-low groups based on ESTIMATE scores, stromal scores, and Immune scores. (B) Comparison of immune cell subsets between CEL-low and CEL-high groups. (C) CEL expression is correlated with immune infiltration in PDAC as analyzed using the TIMER database. (D) Heatmap of 8 immune checkpoints between CEL-low and CEL-high groups. (E) CEL expression in different immune subtypes of PDAC. C1, wound healing; C2, IFN-gamma dominant; C3, inflammatory; C4, lymphocyte depleted; C5, immunologically quiet; C6, TGF-b dominant. PDAC, pancreatic ductal adenocarcinoma; ns, no significance. ∗p < 0.05; ∗∗p < 0.01; and ∗∗∗p < 0.001.