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. 2023 Jul 12;13:1240676. doi: 10.3389/fonc.2023.1240676

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Copyright © 2023 Wang, Khan, Nabi and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Left: (A) Circadian rhythm modulates physiological behavior by regulating hormonal release. (B) Circadian system interacts with pathways associated with metabolism and cellular homeostasis. Disrupted circadian clock induces cancer progression and development; normal rhythms can be restored by chronotherapeutic interventions to improve the efficacy anticancer therapeutics/treatments. Right: PER1 can cause reversal of trastuzumab resistance. (A) Injecting transfected NCI-N87TR cells into nude mice and measurement of glycolysis level shown PET-CT images, where white circles detect location of the tumor. (B) Standard uptake value (mean values), (C) PER1 and HK2 expression indicated by IHC images, (D) Levels of PER1 and HK2 detected by quantitative analysis, (E) Tumor growth in response to the treatment with trastuzumab and PER1 knockdown, (F) Ki67 and cleavage of caspase-3 detected by IHC images. This figure was adopted from Wang et al. (6).