Table 2.

Baseline cardiovascular and cerebrovascular data.

Baseline variables	Model 1: Age			Model 2: Age and Sex (M = 30 F = 34)					Model 3: Interaction (Age × Sex)
				Age		Sex
	P-value	R2	β	P-value	β	P-value	β	R2	P-value	R2	β Males	β Females
PCAv (cm/s)	0.013	0.096	−0.19 ± 0.07	0.011	−0.19 ± 0.07	0.20	3.15 ± 2.45	0.12	0.001	0.26	0.02 ± 0.09	−0.42 ± 0.10
CVRi (mmHg/cms−1)	<0.001	0.24	0.021 ± 0.005	<0.001	0.021 ± 0.005	0.68	0.067 ± 0.16	0.25	0.019	0.31	0.011 ± 0.006	0.032 ± 0.007
CVC (cms−1/mmHg)	<0.001	0.22	−0.004 ± 0.001	<0.001	−0.004 ± 0.001	0.23	0.036 ± 0.029	0.24	0.002	0.36	−0.001 ± 0.001	−0.006 ± 0.001
MAP (mmHg)	<0.001	0.32	0.40 ± 0.07	<0.001	0.40 ± 0.08	0.64	−1.2 ± 2.6	0.33	0.93	0.33	0.40 ± 0.10	0.41 ± 0.11
PETCO2 (mmHg)	0.37	0.013	−0.036 ± 0.04	0.39	−0.034 ± 0.04	0.41	−1.1 ± 1.4	0.024	0.03	0.098	−0.11 ± 0.05	0.06 ± 0.06
Heart Rate (bpm)	0.52	0.007	0.037 ± 0.057	0.54	0.035 ± 0.057	0.48	−1.4 ± 1.9	0.015	0.53	0.021	0.001 ± 0.079	0.074 ± 0.084

Data presented as mean ± SD. Bold indicated significant relationship (P < 0.05). Model 1 presents the relationship between age and the indicated variable. Model 2 presents the addition of sex to the model and the relationship between age and sex with the indicated variable. Model 3 indicates if sex moderates the relationship between age and the indicated variable, with individual beta-coefficients shown for males and females. In model 1,2 and 3 the R² value reflects the full model. In model 1 and 3 β represents the unstandardised beta coefficient representing the change in variable units for every year increase in age. In model 2 the β coefficient provides the difference in females vs males in the variable units. PCAv: posterior cerebral artery velocity; CVRi: cerebrovascular resistance index; CVC: cerebrovascular conductance index; MAP: mean arterial pressure; P_ETCO₂: end-tidal carbon dioxide.