FIGURE 1.

The effects of cocaine- versus placebo-priming, money-alternative amount ($0.50 vs. $1.50 per choice), and NAC versus placebo on mean (±1 SEM) cocaine breakpoint values (10 mg unit dose) are depicted. Relative to placebo-priming, cocaine-priming significantly increased cocaine breakpoint, F(1,11) = 14.11, **p = .003, partial η² = 0.56, very large effect (**solid line). Relative to the $0.50 money alternative, the $1.50 money alternative significantly decreased cocaine breakpoint for placebo- and cocaine-priming, F(1,11) = 9.35, *p = .011, partial η² = 0.46, large effect (*solid lines). Relative to the placebo dose, NAC (3600 mg/day) attenuated the effect of cocaine-priming on cocaine breakpoint, F(1,11) = 5.19, *p = .044, partial η² = 0.32, large effect (*dashed line). For comparison, the rightmost bar indicates cocaine (10-mg unit dose vs. placebo [no money] choice) breakpoint during the reinforcement screening session (R+) prior to medication exposure