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. 2023 May 10;10(20):2207334. doi: 10.1002/advs.202207334

Figure 9.

Figure 9

Adipose‐derived stem cells (ADSCs) combined with articular cartilage extracellular matrix (ACECM) promote cartilage regeneration. A) Overview of experimental design. (a) Representative images of defects treated with phosphate‐buffered saline (PBS) (negative control), ADSCs, CD146+ ADSCs, and the sham‐operated group at 2 weeks following surgery. (b) Histological analysis of the defected area using hematoxylin and eosin (H&E), safranin O, and toluidine blue. Black solid arrows denote the repair interface. Red solid arrows denote the depth of the repaired cartilage. HC, host cartilage; D, defect area; RC, repaired cartilage. Reproduced under terms of the CC‐BY license.[ 175 ] Copyright 2022, Ivyspring International Publisher. B) General joint observations (left) and longitudinal section (right) of the cartilage regeneration at 3 months after surgery. Reproduced with permission.[ 176 ] Copyright 2020, John Wiley and Sons.