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. 2023 May 10;10(20):2207334. doi: 10.1002/advs.202207334

Figure 11.

Figure 11

Adipose‐derived stem cells (ADSCs) promote peripheral nerve regeneration. A) Schematic of the preparation process of the ADSCs‐laden polylysine‐decorated macroporous chitosan microcarriers (pl‐CSMCs) and their application in nerve repair. (a) Representative images and hematoxylin and eosin (H&E) staining of the regenerated nerve tissue at the midportion of the nerve guide conduits (NGCs) or autograft 12 weeks after implantation. Yellow arrows indicate blood vessels. Reproduced under terms of the CC‐BY license.[ 202 ] Copyright 2021, The Authors, Published by Elsevier. B) Schematic illustration of magnetic targeted ADSCs therapy. (b) Analysis of semithin sections of axonal bundles in uninjured control sciatic nerve and the distal stump of non‐transplanted, transplanted with ADSCs and ADSCs‐superparamagnetic iron oxide nanoparticles (SPIONs) transplanted group at 7 days post‐injury. Arrows indicate intact axons; arrowheads indicate irregular axons; asterisks indicate myelin and axon debris. Reproduced with permission.[ 203 ] Copyright 2021, Elsevier.