Skip to main content
. 2023 May 8;10(20):2300115. doi: 10.1002/advs.202300115

Figure 4.

Figure 4

The function of LIST in xenograft tumor models and organoid models. A,B) Xenograft tumor models using BALB/c nude mice (n = 5) were used to examine the effect of LIST A) overexpression or B) knockdown on tumor growth and chemoresistance in vivo. Images, weights, and growth curves of the tumors are presented. GT therapy was based on a combination of gemcitabine and paclitaxel. Error bars represent the mean ± SD of the tumors (*p < 0.05, **p < 0.01, ***p < 0.001), Student's t‐test. C,D) Organoid growth was examined by measuring organoid volume at multiple time points upon LIST overexpression or knockdown. E,F) Apoptotic cells (green) were stained using the caspase 3/7 activity apoptosis assay kit in bladder carcinoma organoid upon LIST overexpression or knockdown. PTX (paclitaxel), 0.05µM; DDP (cisplatin), 5µM. Scale bar: 20 µm.