Figure 6.

C. albicans triggered immunosuppressed T cell responses by inducing macrophage M2‐like phenotype switch. a) The types of macrophages in blood and spleen were examined by flow cytometry using CD11c, CD11b, and F4/80⁺ as detection markers, n = 4 per group. b,c) The expression of CD206 in RAW cells stimulated by Sap2‐273L, Sap2‐273V strains, or LPS was detected by flow cytometry. d) The cytokine ARG‐1 level was detected by qPCR. e) Co‐localization of BMDM cells (CD206⁺, pink) and C. albicans (CFSE⁺, green) was detected by immunofluorescent staining. f,g) IL‐10 and TGF‐β transcription level upon co‐culture of RAW cells with Sap2‐273L or Sap2‐273V for 3 and 6 h. Data are shown as means ± SD, and from one of three independent experiment. p values were analyzed by Student's t‐test. *p < 0.05, **p < 0.01.