Table 2.
Infant characteristics of infants born at 29 to 33 weeks’ GA in NRN centers from 2012 to 2013 by 2 maternal receipts of insulina
| Infant characteristics | Mother received insulin (IDDM) N = 527 | Mother did not receive insulin (no IDDM) N = 6,509 | p-Valueb |
|---|---|---|---|
| Death within 12 hours | 3/527 (0.6) | 47/6,509 (0.7) | 1.00 |
| Outborn | 31/527 (6) | 589/6,509 (9) | 0.01 |
| GA (wk) | |||
| 29 | 61 (12) | 751 (12) | 0.98 |
| 30 | 78 (15) | 987 (15) | 0.82 |
| 31 | 97 (18) | 1,156 (18) | 0.71 |
| 32 | 123 (23) | 1,582 (24) | 0.62 |
| 33 | 168 (32) | 2,033 (31) | 0.76 |
| Birth weight, g | |||
| Mean (SD) | 1,824 (530) | 1,685 (410) | < 0.001 |
| < 1,000 | 19 (4) | 271 (4) | 0.54 |
| 1,000–1,500 | 131 (25) | 1,929 (30) | 0.02 |
| 1,500–2,000 | 197 (38) | 2,916 (45) | 0.001 |
| 2,000–2,500 | 130 (25) | 1,206 (19) | < 0.001 |
| > 2,500 | 49 (9) | 185 (3) | < 0.001 |
| Birth weight z-score, mean (SD) | 0.41 (1.43) | −0.05 (1.09) | < 0.001 |
| Length at birth, cm | N = 521 | N = 6,437 | |
| Mean (SD) | 42.3 (3.7) | 41.7 (3.4) | < 0.001 |
| Length z-score | 0.18 (1.16) | −0.06 (1.04) | < 0.001 |
| Head circumference at birth, cm | N = 522 | N = 6,420 | |
| Mean (SD) | 29.3 (2.3) | 29.0 (2.1) | 0.03 |
| Head circumference z-score | 0.12 (1.25) | −0.03 (1.12) | 0.008 |
| Small for GA | 52/525 (10) | 785/6,504 (12) | 0.14 |
| Large for GA | 110/525 (21) | 604/6,504 (9) | < 0.001 |
| Male | 266/526 (51) | 3,402/6,506 (52) | 0.45 |
| Apgar at 1 minute ≤3 | 100/526 (19) | 1,101/6,460 (17) | 0.25 |
| Apgar at 5 minutes ≤3 | 13/525 (3) | 203/6,464 (3) | 0.40 |
| Delivery room interventions | N = 525 | N = 6,502 | |
| Oxygen | 381/525 (73) | 4,506/6,502 (69) | 0.12 |
| Bagging and mask | 218/525 (42) | 2,686/6,500 (41) | 0.93 |
| CPAP | 312/527 (59) | 3,338/6,501 (51) | < 0.001 |
| Intubation | 82/527 (16) | 1,105/6,504 (17) | 0.40 |
| Chest compression | 6/527 (1) | 169/6,503 (3) | 0.04 |
| Epinephrine | 5/527 (1) | 77/6,503 (1) | 0.63 |
| Ventilator support | 12/495 (2) | 122/6,074 (2) | 0.53 |
| Surfactant therapy | 132/527 (25) | 1,693/6,507 (26) | 0.63 |
| Major birth defect | 59/527 (11) | 561/6,506 (9) | 0.045 |
Abbreviations: CPAP, continuous positive airway pressure; GA, gestational age; IDDM, insulin–dependent diabetic mellitus mothers; No IDDM, no insulin-dependent diabetes mellitus; PROM, prolonged rupture of membranes.
a
All data presented as n (%) unless otherwise specified.
b
Comparisons by chi square, Fisher’s exact, or Student’s t-test where appropriate.