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. 2023 Jul 26;15(3):e12453. doi: 10.1002/dad2.12453

FIGURE 3.

FIGURE 3

Cognitively normal trajectories: a, Harmonization cohort, b, AIBL Validation cohort. Expected trajectories for an Aβ– (blue) and an Aβ+ (red) 70‐year‐old women with an education of 14 years with no cognitive impairment (i.e., CN) at baseline. Clinically impaired trajectories: c, Harmonization cohort, d, AIBL Validation cohort. Plots show the expected trajectories for an Aβ− (blue) and an Aβ+ (red) 70‐year‐old woman with an education of 14 years with cognitive impairment (i.e., MCI or AD) at baseline. e, Braak stage trajectories. Expected trajectories for an Aβ+ 70‐year‐old woman with an education of 14 years who is tau negative (green), tau Braak I positive (blue), tau Braak III/IV positive (red), and tau Braak V/VI positive (black). Error bars represent standard deviation of the residual of the fit from the LME. Numbers below the plots show the sample size at different years of follow‐up. Discriminatory power of CC‐ACC for baseline Aβ status for MCI patients. f, Harmonization cohort, g, ADNI cohort, h, AIBL Validation Cohort. AUC of the receiver operating characteristic curve for a logistic regression predicting baseline Aβ. Blue bars represent the AUC for either the baseline CC‐ACC or the annualized rate of change of the CC‐ACC at different durations of follow‐up. Red bars represent the AUC for either the baseline MMSE or the annualized rate of change of the MMSE at different durations of follow‐up. Yellow bars represent the AUC for either the baseline PACC or the annualized rate of change of the PACC at different durations of follow‐up. Error bars indicate the standard deviation of the AUC across bootstraps. Aβ, amyloid beta; AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; AIBL, Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing; AUC, area under the curve; CN, cognitively normal; CC‐ACC, Cross‐Cohort Alzheimer Cognitive Composite; LME, linear mixed effects; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; PACC, Preclinical Alzheimer Cognitive Composite