Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 29;3(7):1952–1964. doi: 10.1021/jacsau.3c00198

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Not subject to U.S. Copyright. Published 2023 by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Thyclotide exhibits strong binding properties to oligonucleotides. (A) Melting temperatures for PNA–DNA duplexes (1 μM individual strand concentration) in PBS. (B) Melting temperature data for PNA–RNA duplexes (1 μM individual strand concentration) in PBS. (C) Comparison of single base mismatch discrimination between aegPNA, thyclotide, and cpPNA for DNA binding. Color codes for Y in the DNA strand: A (red), T (purple), C (green), and G (blue). (D) Comparison of single base mismatch discrimination between aegPNA, thyclotide, and cpPNA for RNA binding. Color codes for Y in the RNA strand: A (red), U (purple), C (green), and G (blue).