Table 2.

Clinical Information of Patients Treated With Antibiotics for Suspected Bacterial Skin/Soft-Tissue Infection of Mpox Lesions

Age, y	Risk Factors for Severe Disease	High Risk Lesions	Admitted	Mpox diagnosis to Antibiotic Treatment, Days	Antibiotic Prescribed	Location of SSTI	Clinical Features of Interest	Antibiotic Appropriateness
40	None	AG		0	Amoxicillin-clavulanate	Genital	Erythema of penile lesion	Appropriate
23	HIV, controlled; other exfoliative, other immunocompromise	AG	Y: perineal edema	0	Cephalexin	Genital	Soft tissue swelling in groin	Appropriate
40	HIV, controlled	AG		0	Ciprofloxacin + metronidazole	Perirectal	Perirectal collection on CT, treated empirically	Appropriate
43	HIV, controlled	AG		−3	Doxycycline	Rectal + Extremity	Empiric treatment prior to mpox diagnosis, limited documentation	Appropriate
56	None	O		0	TMP/SMX + cephalexin	Oral	Empiric treatment, mpox felt most likely	Inappropriate
22	None	O		0	TMP/SMX + cephalexin	Face	Empiric treatment, treating associated thrombophlebitis and lesions	Appropriate
27	None	O		0	Clindamycin->TMP/SMX + cephalexin	Oral	Empiric treatment, ABX stopped once mpox diagnosed	Inappropriate
34	HIV uncontrolled	O, AG	Y: facial edema	2	TMP/SMX + cephalexin	Face	Honey-crusting of lip lesion	Appropriate
32	HIV uncontrolled	O, AG	Y: pharyngitis	0	Amoxicillin-clavulanate	Face	Facial swelling	Appropriate
36	HIV, controlled			6	Mupirocin	Face	Facial pustule	Appropriate
39	HIV, controlled			8	TMP/SMX + cephalexin	Groin	Groin erythema at mpox lesion	Appropriate
48	HIV, controlled		Y: septic knee	0	TMP/SMX + cephalexin	Extremity	Knee effusion: mpox positive, culture negative	Appropriate
38	HIV, controlled			0	Levofloxacin + doxycycline	Face	Empiric treatment, ABX stopped once mpox diagnosed	Inappropriate

Note. ABX, antibiotics; SSTI, bacterial skin and soft-tissue infection; TM-SMX, trimethoprim/sulfamethoxazole; O, oral lesions; AG, anogenital lesions; HIV, human immunodeficiency virus; CT, computed tomography.