Table 1.

Institutional Dosing Recommendations According to Renal Function for Intermittent (30-minute) Cefepime Infusions

Renal Function a	Severe Infection b	Moderate Infection c
>60 mL/min	2 grams q8h	2 grams q12h
30–60 mL/min	2 grams q12h	2 grams q24h
11–29 mL/min	2 grams q24h	1 gram q24h
<11 mL/min	1 gram q24 h	500 mg q24h
HD	1 gram q24h	1 gram × 1 dose then 500 mg q24h
CVVH (effluent rate 2–2.5 L/h)	2 grams q12h	1 gram q12h

Note. q8h, every 8 hours; q12h, every 12 hours; q 24h, every 24 hours; HD, hemodialysis; CVVH, continuous veno-venous hemofiltration.

^a Determined by Cockroft-Gault equation.

^b Sepsis, meningitis, pneumonia, neutropenic fever, and P. aeruginosa infections.

^c Intra-abdominal, skin and soft tissue, and pyelonephritis infections.