Table 2.

Institutional Dosing Recommendations According to Renal Function for Extended Infusion (3 hour) Cefepime Infusions

Renal Function a	Meningitis	Severe Infection b	Moderate Infection c
>50 mL/min	2 grams q8h	1 gram q6h	1 gram q8h
30–50 mL/min	2 grams q12h	1 gram q8h	1 gram q8h
<30 mL/min	2 grams q24h	1 gram q12h	1 gram q12–24h
HD	2 grams q24h	1 gram q24h	1 gram q24h
CVVH (effluent rate 2–2.5 L/h)	2 grams q12h	1 gram q12h	1 gram q12h

Note. q6h, every 6 hours; q8h, every 8 hours; q12h, every 12 hours; q 24h, every 24 hours; HD, hemodialysis; CVVH, continuous veno-venous hemofiltration.

^a Determined by Cockroft-Gault equation.

^b Sepsis, pneumonia, neutropenic fever, and P. aeruginosa infections.

^c Intra-abdominal, skin and soft-tissue, and pyelonephritis infections.