Table 3.
Demographic Characteristics of Patients Who Received Intermittent- or Extended-Infusion Cefepime
| Characteristic | Intermittent Infusion (n = 111), No. (%) a | Extended Infusion (n = 93), No. (%) a |
|---|---|---|
| Age, median y [IQR] | 65 [55.5–76.5] | 67 [59–78] |
| Sex, male | 47 (42.3) | 42 (45.2) |
| Weight, median kg [IQR] | 75.5 [60.3–93.8] | 74.8 [62–92.2] |
| SCr on cefepime day 1 (mg/dL) | 1.01 [0.74–1.55] | 1.04 [0.73–1.51] |
| WBC on cefepime day 1 (103/uL) c | 10.8 [6.55–17.7] | 12.55 [6.75–18] |
| Additional antibiotic therapy (fluroquinolone or aminoglycoside) c | 11 (9.9) | 5 (5.4) |
| Infectious diseases consultation | 41 (36.9) | 33 (35.5) |
| Cefepime duration, median d [IQR] | 5 [3–7] | 5 [3–7] |
| MS-DRG code c | ||
| 177. Respiratory infections & inflammations with MCC | 7 (6.3) | 7 (7.5) |
| 178. Respiratory infections & inflammations with CC | 4 (3.6) | 3 (3.2) |
| 193. Simple pneumonia & pleurisy with MCC | 9 (8.1) | 8 (8.6) |
| 194. Simple pneumonia & pleurisy with CC | 9 (8.1) | 3 (3.2) |
| 870. Septicemia or severe sepsis with mechanical ventilation >96 h | 4 (3.6) | 5 (5.4) |
| 871. Septicemia or severe sepsis without mechanical ventilation >96 h with MCC | 62 (55.9) | 57 (61.3) |
| 872. Septicemia or severe sepsis without mechanical ventilation > 96 h and without MCC | 16 (14.4) | 10 (10.8) |
| APR-DRG severity of illness score b , c | ||
| 4 Extreme | 52 (46.8) | 39 (41.9) |
| 3 Major | 41 (36.9) | 43 (46.2) |
| 2 Moderate | 17 (15.3) | 8 (8.6) |
| 1 Minor | 1 (0.9) | 3 (3.2) |
| Positive culture source c | 51 (45.9) | 44 (47.3) |
| Blood | 22 (43.1) | 21 (47.7) |
| Sputum | 16 (31.4) | 10 (22.7) |
| Urine | 11 (21.6) | 11 (25) |
| Wound | 2 (3.9) | 1 (2.3) |
| Other | 0 (0) | 1 (2.3) |
| Gram-positive bacteria | 10 (9) | 11 (11.8) |
| Gram negative bacteria c | 40 (36) | 33 (35.4) |
| P. aeruginosa | 9 (22.5) | 5 (15.2) |
| Klebsiella spp | 7 (17.5) | 1 (3) |
| Escherichia coli | 17 (42.5) | 12 (36.4) |
| Enterobacter spp | 2 (5) | 1 (3) |
| Citrobacter spp | 0 (0) | 1 (3) |
| Proteus spp | 2 (5) | 2 (6.1) |
| Burkholderia spp | 1 (2.5) | 0 (0) |
| Sphingomonas spp | 0 (0) | 1 (3) |
| Pantoea spp | 0 (0) | 1 (3) |
| Acinetobacter spp | 0 (0) | 1 (3) |
| Haemophilus influenzae | 0 (0) | 1 (3) |
| Stenotrophomonas spp | 0 (0) | 1 (3) |
| Moraxella spp | 0 (0) | 1 (3) |
| Polymicrobial including NLF species | 2 (5) | 2 (6.1) |
| Polymicrobial not including NLF species | 0 (0) | 3 (9.1) |
Note. IQR, interquartile range; WBC, white blood cell count; SCr, serum creatinine; MS-DRG, medical severity diagnosis-related group; MCC, major complication or comorbidity; CC, complication or comorbidity; APR-DRG, All-Patient Refined Diagnosis-Related Group; NLF, non–lactose-fermenting.
a
Units unless otherwise specified.
b
This report was produced using proprietary computer software created, owned, and licensed by the 3M Company. All Copyrights in and to the 3M APR DRG classification system(s) are owned by 3M. All rights reserved.
c
Statistical tests did not show a significant difference between groups.