Fig. 3.

Regulatory effect of histone modification on oxidative stress in cardiac fibrosis

Histone modifications affect the intracellular oxidative balance of various cardiac tissue cells such as cardiomyocytes, cardiac fibroblasts, and endothelial cells, thereby affecting the process of cardiac fibrosis. Among them, ATF4, peIF2α and CHOP were upregulated as markers of ER stress.