Table 1.

Oxidative stress influences cardiac fibrosis by affecting epigenetic modification.

	DNA methylation	Histone modification	Non-coding RNA
Transformation	●DNA methylation ↑ inactivate RASSF1A activate ERK1/2 [27] Proliferation	●activate DDR signaling pathway SIRT1↓ PGC-1α acetylation [29] Mitochondrial damage ●HDAC4 is transported to the cytoplasm [30] Hypertrophy	●Activate Smad3 miR-29b-3p和miR-29c-3p↓ target TGF-β2 and MMP2 [32] Activation	●redistribution of miR-381–3p between mitochondria and cytoplasm inhibiting LRP6 and NFIA [33] Apoptosis Inhibit proliferation
Cell type	Cardiac fibroblast	Cardiomyocyte	Cardiac fibroblast	Endothelial cell