TABLE 4.
Univariable and Multivariable Analyses for Association with Disease-Free Survival
| Characteristic (N) | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (2398) | 1.04 (1.04–1.05) | <0.001 | 1.04 (1.03–1.05) | <0.001 |
| Sex (2398) | ||||
| Female | — | |||
| Male | 1.02 (0.86–1.22) | 0.8 | ||
| Race (2328) | ||||
| Asian | — | — | ||
| Black | 1.71 (1.03–2.84) | 0.038 | 1.20 (0.69–2.07) | 0.5 |
| White | 1.41 (0.93–2.14) | 0.11 | 1.08 (0.70–1.67) | 0.7 |
| Other | 0.61 (0.14–2.58) | 0.5 | 0.51 (0.12–2.21) | 0.4 |
| Ethnicity (2164) | ||||
| Hispanic or Latino | — | |||
| Not Hispanic | 1.52 (0.91–2.55) | 0.11 | ||
| History of cancer (2398) | ||||
| No | — | — | ||
| Yes | 1.55 (1.23–1.96) | <0.001 | 1.32 (1.01–1.72) | 0.039 |
| ASA (2398) | ||||
| 1 | — | — | ||
| 2 | 1.55 (0.49–4.88) | 0.5 | 0.67 (0.21–2.13) | 0.5 |
| 3 | 3.28 (1.05–10.2) | 0.041 | 1.01 (0.32–3.22) | >0.9 |
| 4 | 6.44 (1.99–20.9) | 0.002 | 1.42 (0.42–4.80) | 0.6 |
| BMI (2376) | 1.00 (0.99–1.02) | >0.9 | ||
| CEA level (2139) | ||||
| <5 | — | — | ||
| ≥5 | 1.67 (1.38–2.01) | <0.001 | 1.32 (1.07–1.62) | 0.009 |
| Albumin level (2353) | 0.56 (0.46–0.68) | <0.001 | 0.86 (0.67–1.10) | 0.2 |
| Tumor location (2398) | ||||
| Left colon | — | — | ||
| Mid-transverse colon | 1.02 (0.72–1.43) | >0.9 | 0.75 (0.51–1.12) | 0.2 |
| Right colon | 1.38 (1.14–1.66) | <0.001 | 1.05 (0.85–1.30) | 0.6 |
| Colectomy extent (2398) | ||||
| Extended | — | |||
| Segmental | 1.24 (0.85–1.82) | 0.3 | ||
| Tumor grade (2318) | ||||
| Low | — | — | ||
| High | 1.51 (1.24–1.86) | <0.001 | 1.11 (0.88–1.40) | 0.4 |
| N category (2398) | ||||
| 0 | — | — | ||
| 1 | 1.51 (1.23–1.85) | <0.001 | 1.62 (1.28–2.04) | <0.001 |
| 2 | 2.51 (1.98–3.18) | <0.001 | 2.66 (2.00–3.54) | <0.001 |
| T category (2398) | ||||
| CIS or 1 | — | — | ||
| 2 | 0.99 (0.68–1.46) | >0.9 | 1.02 (0.66–1.58) | >0.9 |
| 3 | 1.51 (1.13–2.01) | 0.005 | 1.23 (0.86–1.75) | 0.3 |
| 4 | 2.99 (2.16–4.13) | <0.001 | 1.95 (1.29–2.94) | 0.002 |
| Procedure yr (2398) | ||||
| 2006–2009 | — | |||
| 2010–2014 | 1.03 (0.83–1.27) | 0.8 | ||
| 2015–2018 | 1.16 (0.90–1.50) | 0.2 | ||
| Colectomy approach (2398) | ||||
| Laparoscopic | — | — | ||
| Open | 1.34 (1.09–1.63) | 0.004 | 1.05 (0.84–1.32) | 0.7 |
| Robotic | 0.94 (0.73–1.20) | 0.6 | 1.13 (0.86–1.48) | 0.4 |
HR = hazard ratio; CI = confidence interval; ASA = American Society of Anesthesiologists classification of physical status; BMI = body mass index; CEA = carcinoembryonic antigen; CIS = intramucosal carcinoma in situ.