Table 3.
Laboratory investigations of the studied groups
| Parameters | Controls (n = 50) |
Patients | P-value for J-T | Effect size (95% CI) | Post hoc test | |
|---|---|---|---|---|---|---|
| Cirrhosis (n = 50) |
HCC (n = 50) |
|||||
| Mean ±SD | Mean ±SD | Mean ±SD | ||||
| Hb (g/dl) | 12.9 ±1.2 | 11.8 ±1.1 | 11.9 ±1.0 | < 0.001* | –0.24 [(–0.38)-(–0.08)] | P1, P2 < 0.001, P3 = 0.905 |
| Platelets (103/µl) | 247.9 ±59.6 | 147.8 ±39.3 | 123.9 ±39.6 | < 0.001* | –0.57 [(–0.68)-(–0.45)] | P1, P2 < 0.001, P3 = 0.033 |
| TLC (103/µl) | 6.6 ±2.1 | 4.8 ±1.7 | 5.1 ±1.9 | < 0.001* | –0.23 [(–0.38)-(–0.07)] | P1, P2 < 0.001, P3 = 0.477 |
| Albumin (g/dl) | 4.4 ±0.4 | 3.5 ±0.6 | 3.3 ±0.5 | < 0.001* | –0.49 [(–0.60)-(–0.35)] | P1, P2 < 0.001, P3 = 0.303 |
| Total bilirubin (mg/dl) | 0.5 ±0.1 | 1.2 ±0.7 | 1.5 ±0.7 | < 0.001* | 0.52 [0.39-0.63] | P1, P2 < 0.001, P3 = 0.028 |
| Direct bilirubin (mg/dl) | 0.18 ±0.1 | 0.5 ±0.4 | 0.7 ±0.5 | < 0.001* | 0.55 [0.42-0.66] | P1, P2 < 0.001, P3 = 0.003 |
| ALT (IU/l) | 28.2 ±9.8 | 51.7 ±17.9 | 59.8 ±27.1 | < 0.001* | 0.47 [0.33-0.59] | P1, P2 < 0.001, P3 = 0.090 |
| AST (IU/l) | 26.4 ±8.6 | 47.2 ±19.0 | 59.3 ±25.4 | < 0.001* | 0.49 [0.35-0.61] | P1, P2 < 0.001, P3 = 0.018 |
| AFP (ng/ml) | 3.4 ±1.0 | 15.2 ±33.6 | 476.9 ±1025.6 | < 0.001* | 0.61 [0.48-0.71] | P1, P2, P3 < 0.001 |
Hb – hemoglobin, TLC – total leucocyte count, ALT – alanine aminotransferase, AST – aspartate aminotransferase, AFP – α-fetoprotein, * significant, P1 – difference between controls and cirrhosis, P2 – difference between controls and HCC, P3 – difference between HCC and cirrhosis