Table 6.
Validity of BMP-7 between studied groups
| Parameter | All patients | Cirrhosis vs. controls | HCC vs. controls | HCC vs. cirrhosis | ||||
|---|---|---|---|---|---|---|---|---|
| Value | 95% CI | Value | 95% CI | Value | 95% CI | Value | 95% CI | |
| AUC | 0.774 | 0.698-0.851 | 0.843 | 0.767-0.92 | 0.705 | 0.605-0.806 | 0.696 | 0.593-0.798 |
| Cut-off point | ≥ 114 | ≥ 114 | ≥ 106.25 | ≤ 129 | ||||
| Sensitivity (%) | 71.0 | 58.0-74.0 | 82.0 | 68.0-91.0 | 74.0 | 59.0-85.0 | 72.0 | 57.0-83.0 |
| Specificity (%) | 70.0 | 61.0-79.0 | 70.0 | 55.0-82.0 | 52.0 | 38.0-66.0 | 58.0 | 43.0-72.0 |
| Accuracy (%) | 71.0 | 63.0-78.0 | 76.0 | 66.0-84.0 | 63.0 | 53.0-72.0 | 65.0 | 55.0-74.0 |
| PPV (%) | 83.0 | 73.0-90.0 | 73.0 | 59.0-84.0 | 61.0 | 47.0-73.0 | 63.0 | 49.0-75.0 |
| NPV (%) | 55.0 | 42.0-67.0 | 80.0 | 64.0-90.0 | 67.0 | 50.0-80.0 | 67.0 | 51.0-80.0 |
PPV – positive predictive value, NPV – negative predictive value