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. 2023 Jul 26;23:699. doi: 10.1186/s12885-023-11045-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — 37-mer peptide dose-dependent cytotoxicity. A SNU449 displayed a significant decrease in cell viability (approx. 50%) upon treatment with peptide (71.2 μM) at 24 h. B Treatment of SNU449 for 48 h with peptide showed a similar trend to 24 h treatment. Cells also experienced significant cell death (approx. 60% viability) at 71.2 μM exposure. C SNU449 cells were screened with 48 h treatment of Cisplatin. 7 μM of cisplatin treated SNU449 showed similar cell viability to peptide treatment (71.2 μM). D 1BR-hTERT cells were treated with the peptide for 24 h. Cells showed similar viability (approx. 50%) at a lower treatment concentration (60.8 μM) compared to SNU449 cells (71.2 μM). E HepG2 peptide treatment at 24 h displayed similar viability (approx. 50%) at a lower concentration (30.4 μM) compared to more advanced hepatocellular carcinoma SNU449 cells (71.2 μM). F SKOV3 treated with peptide for 24 h showed a decrease in cell viability (approx. 80%) at 24 μM. Treatment with 33 nM of Cisplatin reduced cell viability by approx. 50%. SKOV3 displayed greater sensitivity to the peptide, as cytotoxicity started to decrease from 0.24 μM of treatment. (** P < 0.01, *** P < 0.001, **** P < 0.0001, n = 3)