Fig. 4.

Representation of neuritic pathology using Campbell–Switzer silver stain. A Cortex regions, B amygdala, and C hippocampus. 5xFAD TAU mice show larger and more intense neuritic halos (dark stain) around amyloid plaques. Quantification of average size in µm² of each staining per area (for each mouse model the following CS plaques bigger than 60 µm² were selected: cortex, n = 1000–2000; amygdala, n = 200–300; and hippocampus, n = 100–130) was calculated using Image-Pro software (Version 10.0.4, Media Cybernetics). Scale bars 40 µm