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. 2023 Jul 26;20:174. doi: 10.1186/s12974-023-02823-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Dystrophic appearance of astrocytes in 5xFAD TAU mouse brains. A Immunofluorescent staining of Aβ (6E10), astrocytes (GFAP) and microglia (CD11b) in 5xFAD and 5xFAD TAU mice, Scale bar = 500 µm. B Quantification of mean intensity of GFAP and CD11b-positive staining within the hippocampus of 5xFAD vs. 5xFAD TAU mice normalized to WT. C Co-staining of GFAP-Aβ in the brain of 5xFAD vs. 5xFAD TAU mice show dystrophic appearance of astrocytes in 5xFAD TAU mice around Aβ plaques. Scale bar = 50 µm