Table 2.
Comparison of COVID19 and non-infection groups among AIRD patients on background therapy with tofacitinib
| Variables N = 335 |
COVID19 N = 36 |
Non-COVID19 N = 299 |
p-value | Odds Ratio |
|---|---|---|---|---|
| Age in years | 51.5 ± 12.73 | 48.28 ± 11.96 | NS# | |
| Gender M (F) | 10 (26) | 55 (244) | NS* | 1.71 (0.78–3.74) |
| Duration of AIRD in months | ||||
| < 24 Months | 5 (13.89%) | 55 (18.39%) | 0.34$ | 0.72 (0.27–1.92) |
| ≥ 24 Months | 31 (86.11%) | 244 (81.61%) | ||
| Smoking | 0 | 5 (1.67%) | NS$ | - |
| DM | 9 (25.0%) | 34 (11.37%) | 0.04* | 2.60 (1.13–5.99) |
| HTN | 11 (30.56%) | 60 (20.07%) | NS* | 1.75 (0.82–3.76) |
| Obesity BMI > 30 | 3 (8.33%) | 8 (2.68%) | NS$ | 3.34 (0.84–13.08) |
| Asthma/ILD | 2 (5.56%) | 7 (2.34%) | NS$ | 4.22 (1.38–12.94) |
| Diagnosis | ||||
| RA | 25 (69.44%) | 221 (73.91%) | < 0.0001* | 0.8 (0.38–1.71) |
| PsA | 4 (11.11%) | 25 (8.36%) | < 0.0001$ | 1.37 (0.45–4.19) |
| SpA | 6 (16.67%) | 29 (9.7%) | NS* | 1.86 (0.72–4.85) |
| Others | 1 (2.78%) | 24 (8.03%) | NS$ | 0.33 (0.04–2.50) |
| Hospitalization | 10 (27.78%) | 0 | NA | - |
| Medications | ||||
| ACEi | 0 | 2 (0.67%) | NS$ | - |
| ARB | 5 (13.89%) | 14 (4.68%) | NS$ | 3.28 (1.11–9.73) |
| Glucocorticoid | 13 (36.11%) | 137 (45.82%) | NS* | 0.67 (0.33–1.37) |
| Methotrexate | 19 (52.78%) | 212 (70.9%) | 0.04* | 0.46 (0.23–0.92) |
| HCQ | 7 (19.44%) | 105 (35.12%) | NS* | - |
| Leflunomide | 5 (13.89%) | 43 (14.38%) | NS$ | 0.96 (0.35–2.61) |
| Apremilast | 0 | 2 (0.67%) | NS$ | - |
| Iguratimod | 1 (2.78%) | 1 (0.33%) | NS$ | 8.51 (0.52-139.61) |
| Sulfasalazine | 3 (8.33%) | 9 (3.01%) | NS$ | 2.93 (0.76–11.36) |
| Aspirin | 1 (2.78%) | 1 (0.33%) | NS$ | 8.51 (0.52-139.61) |
| Anticoagulants | 0 | 1 (0.33%) | NS$ | - |
| Other Drugs | 18 (50.0%) | 157 (52.51%) | NS* | 0.9 (0.45–1.81) |
| Vaccination status | ||||
| COVID-19 vaccination | 5 (13.89%) | 156 (52.17%) | < 0.0001* | 0.15 (0.06–0.39) |
The above is the comparison of parameters between patients who were Infected & Non Infected. To find the Statistical difference #t-test (http://vassarstats.net/tu.html) is used for Continuous variables & *Chi-square test (http://vassarstats.net/newcs.html) & $fisher exact (http://vassarstats.net/tab2x2.html) for categorical variables
DM: Diabetes Mellitus; HTN- Hypertension; BMI- Body Mass Index; ILD-Interstitial Lung Disease; RA: Rheumatoid Arthritis; PsA: Psoriatic Arthritis; SpA- Spondyloarthritis; ACEi -Angiotensin-converting enzyme inhibitor; ARBs-Angiotensin receptor blockers; HCQ- Hydroxychloroquine