Table 2.
Effects of estradiol and selected antihyperlipidemic drugs on plasma lipid profile of ovariectomized Wistar rats fed with thermoxidized palm oil diet
| Treatment | Plasma Lipid profile parameters (mg/dL) | ||||
|---|---|---|---|---|---|
| T-CHOL | TRIG | HDL | LDL | VLDL | |
| Sham (Group I) | 77.72 ± 1.29 | 96.23 ± 10.22 | 22.08 ± 0.77 | 36.40 ± 2.24 | 19.25 ± 2.04 |
| OVX | 93.58 ± 4.76 | 104.12 ± 2.01 | 21.18 ± 0.79 | 49.62 ± 0.86 | 21.3 ± 1.34 |
| OVX + TPO | 106.95 ± 2.70# | 163.95 ± 16.53# | 20.92 ± 0.60 | 55.66 ± 4.73# | 30.37 ± 3.63# |
| OVX + TPO + ATV | 82.49 ± 2.25*** | 110.45 ± 18.34*** | 21.48 ± 1.54 | 38.92 ± 4.62*** | 22.09 ± 3.67** |
| OVX + TPO + EZE + ATV | 98.54 ± 0.66 | 114.89 ± 6.68*** | 20.73 ± 0.69 | 54.83 ± 1.95 | 22.98 ± 1.34* |
| OVX + TPO + ETD | 95.33 ± 1.69** | 126.19 ± 12.78* | 19.54 ± 1.25 | 50.55 ± 5.32 | 25.24 ± 2.56 |
Values are expressed as mean ± standard error of mean (n = 6)
#p < 0.05 compared to Sham accepted as significant
*p < 0.05 compared to OVX + TPO
**p < 0.01 compared to OVX + TPO
***p < 0.001 compared to OVX + TPO
OVX – ovariectomized; TPO – thermoxidized palm oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; TC – total cholesterol; TG – Triglycerides; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; VLDL-c – very low density lipoprotein cholesterol.