Table 4.
Effects of estradiol and selected antihyperlipidemic drugs on plasma atherogenic indices of ovariectomized Wistar rats fed with thermoxidized palm oil diet
| Treatment | Plasma Atherogenic indices | ||
|---|---|---|---|
| AI | CRI | HDL-c/LDL-c | |
| Sham (Group I) | 3.44 ± 0.59 | 3.55 ± 0.22 | 0.62 ± 0.05 |
| OVX | 4.71 ± 0.55 | 4.65 ± 0.33# | 0.3 ± 0.04 |
| OVX + TPO | 6.29 ± 0.92# | 5.09 ± 0.21# | 0.38 ± 0.02 |
| OVX + TPO + ATV | 4.21 ± 0.81*** | 3.88 ± 0.20** | 0.57 ± 0.06 |
| OVX + TPO + EZE + ATV | 4.58 ± 0.39* | 4.78 ± 0.17 | 0.38 ± 0.02 |
| OVX + TPO + ETD | 4.39 ± 0.29** | 5.03 ± 0.52 | 0.42 ± 0.06 |
Values are expressed as mean ± standard error of mean (n = 6)
# - p < 0.05 compared to Sham accepted as significant
* - p < 0.05 compared to OVX + TPO
** - p < 0.01 compared to OVX + TPO
*** - p < 0.001 compared to OVX + TPO
OVX – ovariectomized; TPO – thermoxidized palm oil; ATV – atorvastatin; EZE – ezetimibe; ETD – estradiol; HDL-c – high density lipoprotein cholesterol; LDL-c – low density lipoprotein cholesterol; AI – atherogenic index; CRI – coronary risk index.