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. 2023 Jul 26;21:240. doi: 10.1186/s12951-023-01968-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Nanoliposome delivery system of AML treatment. Note: (A) The procedure of loading arsenic into liposomes, (A-a) Hydration of dried lipids, (A-b) Gel exclusion chromatography.(A-c) Addition of As₂O₃ solution into liposomes,(A-d) Influx of H₃AsO₃ into liposome, (A-e) plotted of the novel nano-liposomes. (B) TEM images of liposomes encapsulating a solution of pH 7.4 (Lip(NaCl), B-a and B-d), pH 7.1 (Lip(Ni), B-b and B-e), pH 7.2 (Lip(Co), B-c and B-f), respectively. These samples of a, b and c were stained with 4% uranyl acetate; the samples of d, e and f were unstained and the micrographs show discrete electron-dense inorganic cores within the liposomes. (C) Temperature and pH-triggered arsenic release from Lip-(Ni, As). (D) Cytotoxicity of free As₂O₃, Lip(Ni, As), and Lip(Co, As). (Figure source from the reference [58], color figure can be viewed at acs.org.com.)