Table 1.
Characteristics of the included 9 studies
| Study (year) | Species (sex, n = experimental/control group, age) | Weight | Model (method) | Anesthetic | Experimental group | Control group | Outcome index | Intergroup/differences | Duration (weeks) |
|---|---|---|---|---|---|---|---|---|---|
| Wang Yan [22] | Female SD rats (10/10, NG) | NG | Bilateral oophorectomy was performed on rats | ketamine | By oral gavage of Radix Achyranthis Bidentatae (14g/(kg d) | By oral gavage of isometric NS |
(1) BMD (F-BMD, L- BMD) (2) ELASTIC, M-STRESS, M-LORD, STIFFNESS (3) SerumCa, P, ALP, BGP |
(1) P < 0.05 (2) P < 0.05 (3) P < 0.05 |
12 |
| Lang Xiaoqin [23] | Female SD rats(20/20,10 months) | (280 ± 20)g | Bilateral oophorectomy was performed on rats | Chloral hydrate | By oral gavage of Achyranthan (400 mg/(kg d | By oral gavage of isometric NS |
(1) BMD(F-BMD (2) ELASTIC, M-STRESS, M-LORD, STIFFNESS (3) SerumCa, TPACP5b, NTX, CTX (4) SerumOC, BAP (5) OPG, RANKL (6)BGP |
(1) P < 0.05 (2) P < 0.05 (3) P < 0.05 (4) P < 0.05 (5) P < 0.05 (6) P < 0.05 |
12 |
| Gao Changkun [24] | Male Wistar rats (10/10, NG) | 150 g ± 20 g | By oral gavage of tretinoin (70 mg/ kg/d, qd) for 2 weeks | NG | By oral gavage of Radix Achyranthis Bidentatae (14mg/(kg·d) | By oral gavage of isometric NS |
(1) BMD (F-BMD) (2) Serum Ca, P, ALP |
(1) P < 0.05 (2) P < 0.05 | 4 |
| Yang Hao [25] | Female SD rats (10/10, NG) | 270 ~ 290 g | Bilateral oophorectomy was performed on rats | NG | By oral gavage of Achyranthes Bidentata Polysaccharides (8g/( kg· d) | By oral gavage of isometric NS |
(1) BMD (F-BMD) (2) Serum, ALP, BGP, (3) Serum, NTx, TRAP (4) β-catenin, Runx2, mRNA, Osterix |
(1) P < 0.05 (2) P < 0.05 (3) P < 0.05 (4) P < 0.05 |
12 |
| Dong Qunwei [26] | Female SD rats (10/10,8 months) | 267.18 ± 21.1 g | Bilateral oophorectomy was performed on rats | NG | By oral gavage of Achyranthes Bidentata ecdystero (4g/(kg d) | By oral gavage of isometric NS |
(1) BMD (F-BMD, L- BMD) (2) ELASTIC, M-STRESS, M-LORD, STIFFNESS (3) SerumCa, P, ALP, BGP |
(1) P < 0.05 (2) P < 0.05 (3) P < 0.05 |
4 |
| Ren Xinci [27] | Male Wistar rats (8/8, NG) | 180 ~ 220 g | By oral gavage of tretinoin (70 mg/ kg/d, qd) for 2 weeks | NG | By oral gavage of Achyranthes Bidentata saponins (300 mg/(kg· d) | By oral gavage of isometric NS |
(1)BMD(F-BMD) (2) Serum Ca, P |
(1) P < 0.05 (2) P < 0.05 |
4 |
| Yang Guofu [28] | Female SD rats (10/10,6 months) | 280 ~ 320 g | Bilateral oophorectomy was performed on rats | Pentobarbital sodium | By oral gavage of Achyranthes Bdentata saponins (300 g/(kg· d) | By oral gavage of isometric NS |
(1)BMD(F-BMD, L- BMD) (2)Serum, BAP, BGP, TRAP NTx /Cr COLI |
(1) P < 0.05 (2) P < 0.05 |
12 |
| Ren Xinci [29] | Male Wistar rats (8/8, NG) | 180 ~ 220 g | By oral gavage of tretinoin (70 mg/kg/d, qd) for 2 weeks | NG | By oral gavage of Achyranthes Bidentata saponins (300 mg/(kg· d) | By oral gavage of isometric NS |
(1) BMD (F-BMD) (2) Serum ALP, Ca, P |
(1) P < 0.05 (2) P < 0.05 |
4 |
| Gao Weihu [30] | Female SD rats (12/12, 10 months) | 280 ~ 320 g | Bilateral oophorectomy was performed on rats | Chloral hydrate | By oral gavage of Radix Achyranthis Bidentatae (1.5g/(kg d) | By oral gavage of isometric NS |
(1) BMD (F-BMD) (2) M-STRESS (3) SerumCa, P, ALP BGP |
(1) P < 0.05 (2) P < 0.05 (3) P < 0.05 |
12 |