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. 2023 Jul 25;11:73. doi: 10.1186/s40364-023-00511-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Clinical biopsy and treatment timeline and genetic characterization. (A) Clinical timeline of pre- and post-PIKTOR biopsies, time on PIKTOR treatment and follow-on therapies. Time 0 set at Day 1 of PIKTOR regimen. Arrows indicate survival at last follow up as indicated. (B) Oncoprint summarizing somatic mutations and copy number alterations in known oncogenic driver genes from COSMIC cancer gene consensus in pre-PIKTOR biopsies. Only recurrently altered genes are shown (see Supplemental Table 3 for full variant list). Patients are separated by long-term response, and genes are grouped by patterns of alteration in responders and non-responders