Table 2.

Distribution of meningioma H3K27me3 loss according to clinical and histopathological characteristics. Total counts only include cases if stratification was reported by publications

Parameter	Total n	H3K27me3 Retained, n (%)	H3K27me3 Lost, n (%)	p
Sex
Male	695	578 (83.2)	117 (16.8)	< 0.001
Female	1362	1235 (90.7)	127 (9.3)
Tumor
Primary	1365	1271 (93.1)	94 (6.9)	< 0.001
Recurrent	451	316 (70.1)	135 (29.9)
Adjuvant radiotherapy
No	1279	1128 (88.2)	151 (11.8)	< 0.001
Yes	222	162 (73.0)	60 (27.0)
Extent of resection
GTR	503	365 (72.6)	138 (27.4)	0.79
STR	163	120 (73.6)	43 (26.4)
Simpson grade
I/II/III	1243	1091 (87.8)	152 (12.2)	0.40
IV/V	500	446 (89.2)	54 (10.8)
WHO grade
I	1468	1363 (92.8)	105 (7.2)	< 0.001
II	736	611 (83.0)	125 (17.0)
III	168	108 (64.3)	60 (35.7)
Subtype
I
Meningothelial	694	674 (97.1)	20 (2.9)	< 0.001
Fibroblastic	111	105 (94.6)	6 (5.4)
Transitional	154	150 (97.4)	4 (2.6)
Psammomatous	59	57 (96.6)	2 (3.4)
Angiomatous	33	33 (100)	0 (-)
Microcystic	32	32 (100)	0 (-)
Secretory	39	39 (100)	0 (-)
Lymphocyte rich	2	2 (10)	0 (-)
Metaplastic	17	17 (100%)	0 (-)
II
Atypical	411	372 (90.5)	39 (9.5)
Chordoid	39	34 (87.2)	5 (12.8)
Clear cell	2	2 (100)	0 (-)
III
Anaplastic	84	66 (78.6)	18 (21.4)
Rhabdoid	6	5 (83.3)	1 (16.7)
Papillary	1	1 (100)	0 (-)
Tissue age (< 5 years)
Yes	275	221 (80.4)	54 (19.6)	< 0.001
No	2088	1850 (88.6)	238 (11.4)
Staining loss threshold
> 50% Absent	380	290 (76.3)	90 (23.7)	< 0.001
> 95% Absent	1983	1781 (89.8)	202 (10.2)

Chi-square test of proportions. GTR: Gross-total resection, STR: Sub-total resection, WHO: World Health Organization