Table 4.
Distribution of meningioma H3K27me3 loss across different tissue specimen ages and staining loss thresholds after sub-dividing by WHO Grade
| Parameter | Total, n |
H3K27me3 Retained, n (%) | H3K27me3 Lost, n (%) |
p |
|---|---|---|---|---|
| WHO grade 1 | ||||
| Tissue age < 5 Years | 102 | 101 (99.0) | 1 (1.0) | 0.012 |
| Any tissue age | 1366 | 1262 (92.4) | 104 (7.6) | |
| WHO grade 2 | ||||
| Tissue Age < 5 Years | 162 | 123 (75.9) | 39 (24.1) | 0.006 |
| Any tissue age | 574 | 488 (85.0) | 86 (15.0) | |
| WHO grade 3 | ||||
| Tissue age < 5 Years | 26 | 12 (46.2) | 14 (53.8) | 0.036 |
| Any tissue age | 142 | 96 (67.6) | 46 (32.4) | |
| WHO grade 1 | ||||
| Staining Absent > 50% | 131 | 125 (95.4) | 6 (4.6) | 0.258 |
| Staining Absent > 95% | 1400 | 1299 (92.8) | 101 (7.2) | |
| WHO grade 2 | ||||
| Staining Absent > 50% | 155 | 114 (73.5) | 41 (26.5) | < 0.001 |
| Staining Absent > 95% | 581 | 497 (86.5) | 84 (14.5) | |
| WHO grade 3 | ||||
| Staining Absent > 50% | 94 | 51 (54.3) | 43 (45.7) | 0.002 |
| Staining Absent > 95% | 74 | 57 (77.0) | 17 (23.0) |
Chi-square test of proportions. WHO: World Health Organization