Fig. 6.

Pathogens and commensals signatures in Darier skin. A Network analysis of DD representative gene clusters. The gene network of differentially expressed DEGs between IDS and NIDS was designed on Cytoscape 3 and gene clusters were identified with ClusterViz using the molecular complex detection algorithm (MCODE). B Representative gene clusters with taxa-associated host signatures. Key bacterial species on DD skin show significantly positive (red) or negative correlations (blue) with genes from different functional clusters. Linear correlations between epidermal repair or antimicrobial defence clusters reveal significant correlations with C, D key pathogens and E, F skin commensals relative abundances. Correlations were calculated on R program and significance was adjusted for FDR