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. 2023 Jul 11;13:1203821. doi: 10.3389/fonc.2023.1203821

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Copyright © 2023 Wu, Wang, Zhang, Yuan, Ju, Wang, Chen, Cao, Cai, Ni and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The piR-017724 inhibits HCC development by silencing PLIN3. (A) Prediction of piR-017724 targeted proteins by high-throughput sequencing technology. (B) qRT-PCR detected the expression of PLIN3 in SMMC-7721 cells after transfection. (C) qRT-PCR detects the expression of PLIN3 in PLC/PRF/5 cells after transfection. (D) Analysis of PLIN3 expression levels in HCC tissues on the TIMER2.0 database. (E) Analyze the expression level of PLIN3 in HCC tissues on the GEPIA database. (F) Analysis of the expression level of PLIN3 in different pathological stages on the GEPIA website. (G) The survival of patients in the PLIN3 high expression group was significantly lower than that in the PLIN3 low expression group. *P <0.05, **P <0.01, ***P <0.001.